Zac Efron (along with his girlfriend Vanessa Hudgens, Dakota Fanning and Kristen Bell, among others) appear in Stand Up to Cancer's new "Change the Odds" PSA, which delivers some alarming statistics. In the United States, one in two men and one in three women will battle with cancer, but after watching this video, we have some hope that we can change those numbers!

Stand Up To Cancer's upcoming television fundraising event will be cast live on September 10 on ABC, CBS, NBC, Fox, HBO, Discovery, MLB Network, VH1, HBO Latino, Showtime, E!, The Style Network, G4, and TV One.