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Get ready little monsters, Mother Monster is making her big screen debut!

Lady Gaga will star in Robert Rodriguez's Machete Kills as La Chameleon. The Grammy winner confirmed the exiting news on Twitter, writing, "Yes its true, I will be making my debut as an actress in the amazing MACHETE KILLS BY @RODRIGUEZ."

Gaga joins an impressive cast! Vanessa Hudgens, Sofia Vergara, William Sadler, Demian Bichir, Michelle Rodriguez, Mel Gibson and Charlie Sheen have all signed on to the flick as well.

The director is already enamored with the "Born This Way" singer, tweeting, "I just finished working with @LadyGaga on @MacheteKills. She kicked SO MUCH A**! Holy Smokes. Blown away!"

The film is slated to hit theaters in 2013.